Monthly PROVE Seminars

Latest Seminar

Establishing the Minimal Important Difference

Major international health policy and regulatory authorities have recognizedthe importance of the use of Patient Reported Outcome Measures (PROMs) in clinical research and, to an increasing extent, in clinical practice. Despite the proliferation of PROMs there are substantial challenges in interpreting their results. Users of PROM results -including clinicians, guideline developers and patients -often have no intuitive notion whether an apparent treatment effect is trivial in magnitude, small but important, moderate or large. To address this problem, researchers developed the concept of the minimal important difference (MID): the smallest change in an outcome, either positive or negative, that patients perceive as important. By the end of this talk, the audience will understand 1) what an MID is, 2) why the MID is important, 3) the common approaches used to establish an MID and their strengths and limitations.

Dr. Voineskos is an Associate Professor in the Division of Plastic Surgery and an Investigator at the Li Ka Shing Knowledge Institute at the University of Toronto. He completed his plastic surgery residency training at McMaster University, Canada.

Past Seminars

When Subjective and Objective Outcomes Don’t Align- A Data Based Approach

There has been a paradigm shift in the measurement of clinical and treatment outcomes in the past two decades, with an increasing focus on incorporating …

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Ethical Considerations for the Inclusion of Patient-Reported Outcomes in Clinical Research

Patient-reported outcomes (PROs) can inform health care decisions, regulatory decisions, and health care policy. They also can be used for audit/benchmarking and monitoring symptoms to …

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Assessing Symptomatic Adverse Events in Pediatric Oncology Trials: Enhancing the Children’s Voices

The Federal government mandates that all clinical trials collect and report adverse events to ensure patient safety and to provide data to sponsors, regulators, payers, …

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Evolutions in the Meaning of “Validity” for Measures in Health Care Research: From Accuracy to Argument

Since the 1970s, the field of health measurement has been informed by methodological developments in educational and psychological measurement. In this talk I will discuss …

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The Value of Context in Patient-Reported Outcomes Research and Clinical Care Applications

Over the past 10 years, there has been a considerable increase in use of Patient-Reported Outcomes to both inform individual cancer patient care and better …

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